Supplements · 5 min read · Due Team
Inositol for PCOS: What the Research Actually Says
Inositol has more clinical evidence behind it than almost any other supplement in the PCOS and fertility space. Here's what it does and how to take it.
If you have PCOS and have researched supplements, you've encountered inositol. Unlike many fertility supplements where the evidence is thin, inositol has a meaningful body of clinical research — particularly for PCOS.
What inositol is
Inositol is a naturally occurring compound involved in insulin signaling and cellular messaging. There are two forms relevant to PCOS: myo-inositol (MI) and D-chiro-inositol (DCI).
Why it matters for PCOS
Insulin resistance is a core driver of PCOS for many people. Inositol improves insulin sensitivity, which in turn helps regulate the androgen levels and hormonal signaling that drive irregular ovulation in PCOS.
What the research shows
Multiple randomized controlled trials have found myo-inositol supplementation improves ovulation rates, reduces androgen levels, and lowers fasting insulin in PCOS. Some trials have shown it comparable to metformin for certain outcomes, with fewer side effects.
The right ratio and dosage
Research supports a 40:1 ratio of myo-inositol to D-chiro-inositol. The most studied dose is 4 grams of myo-inositol per day, often split into two doses. Results typically take two to three months.
The bottom line
Inositol is one of the most evidence-supported supplements for PCOS. If you have PCOS and are trying to conceive, it's worth discussing with your provider.
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Chat with Due for a breakdown based on your specific situation.
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